Example sentences of "of [noun sg] [verb] [noun sg] " in BNC.
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| 1 | Role of platelet activating factor on the fibrinolytic activation in the pathogenesis of gastric mucosal damage induced by endothelin-1 |
| 2 | We determined tissue type plasminogen activator activity in the regional blood sample and the concentration of platelet activating factor in the gastric mucosa after the administration of endothelin-1 in a range of 50–500 pmol/ kg into the left gastric artery of male Wistar rats . |
| 3 | In addition we have also investigated the involvement of platelet activating factor in the endothelin induced fibrinolytic activation . |
| 4 | The level of platelet activating factor in the rat gastric mucosa was determined after the administration of endothelin-1 using a radioimmunoassay method . |
| 5 | To assess the involvement of platelet activating factor in the endothelin induced tissue type plasminogen activator activation in gastric mucosa , CV-6209 ( a gift from Takeda Pharm Co ) , a selective platelet activating factor blocker , was intravenously administered at a dose of 0.001–0.1 mg/kg five minutes before the injection of endothelin-1 . |
| 6 | These results suggest the involvement of platelet activating factor in the endothelin induced fibrinolytic activation and subsequently developed mucosal haemorrhagic lesion . |
| 7 | Although the detailed mechanism is unknown , our data raise the possibility that endothelin-1 actually stimulates the production of platelet activating factor followed by the excessive release of tissue type plasminogen activator . |
| 8 | Role of platelet activating factor in pathogenesis of acute pancreatitis in rats |
| 9 | The importance of platelet activating factor in acute pancreatitis was examined by determining the tissue content of endogenous platelet activating factor and the protective effects of TCV-309 , a highly selective platelet activating factor blocker , against caerulein induced pancreatitis in rats . |
| 10 | Infusion of caerulein ( 10 µg/ kg/h ) for five hours resulted in about 70% increase in pancreatic weight , 22% rise in protein content , 50% reduction in tissue blood flow , nine fold increase in tissue level of platelet activating factor and 165% rise in plasma maylase as well as histological evidence of acute pancreatitis . |
| 11 | It has been reported that pancreatic acinar cells , stimulated by caerulein or cholecystokinin , release substantial amounts of platelet activating factor . |
| 12 | Emanuelli et al reported that an injection of platelet activating factor into the superior pancreaticoduodenal artery induced the changes in the rabbit pancreas characteristic of acute pancreatitis . |
| 13 | Development of specific platelet activating factor blockers such as TCV-309 has enabled us to examine the role of platelet activating factor in the pathogenesis of caerulein induced acute pancreatitis . |
| 14 | Male Wistar rats weighing 250–300 g , were used in this study to examine the pancreatic secretion and pancreatic blood flow during infusion of caerulein and to examine the involvement of platelet activating factor in the pathogenesis of acute pancreatitis . |
| 15 | The following series were used ; ( i ) sc infusion of saline ( rate 1 ml/h ) throughout the seven hour experiment ; ( ii ) sc infusion of caerulein ( 10 µg/ kg/h , rate 1 ml/h ) throughout five hour period ; ( iii ) ip injection of TCV-309 ( 50 µg/kg ) in 1 ml of saline ) followed 90 minutes later by sc infusion of caerulein for the rest of experiment ; ( iv ) ip administration of platelet activating factor ( 50 µg/kg ) followed by sc infusion of saline for the duration of experiment ; ( v ) ip injection of TCV-309 followed 30 minutes later by ip platelet activating factor and then by sc infusion of saline for the duration of experiment . |
| 16 | The content of platelet activating factor in pancreatic tissue was determined using bioassay technique with washed rabbit platelets as described previously . |
| 17 | Biological activity of platelet activating factor was measured by platelet aggregation using a Chrono-log Corporation aggregometer . |
| 18 | After determination that sc infusion of caerulein resulted in induction of acute pancreatitis four separate groups of rats , each consisting of six to eight animals were given ( i ) sc infusion of caerulein alone ; ( ii ) ip injection of platelet activating factor ( 50 µg/kg ) , ( iii ) TCV-309 ip ( 50 µg/kg ) and then 30 minutes later sc infusion of caerulein for five hours , and ( iv ) TCV-309 ip ( 50 µg/kg ) and then 30 minutes later platelet activating factor ( 50 µg/kg ip ) and then 30 minutes later sc infusion of saline for five hours . |
| 19 | Administration of platelet activating factor ( 50 µg/kg ip ) caused significant reduction in basal protein secretion by about 30% and this was completely reversed when TCV-309 ( 50 µg/kg ) was administered before the platelet activating factor injection ( Fig 1 ) . |
| 20 | Plasma amylase concentrations rose by about 165% in rats infused with caerulein and 110% after injection of platelet activating factor ( Fig 4 ) . |
| 21 | Pancreatic blood flow as measured by laser Doppler flowmetry at the end of a five hour infusion of caerulein or five hours after injection of platelet activating factor was reduced by about 50% ( Fig 5 ) . |
| 22 | Pretreatment with TCV-309 before the administration of platelet activating factor almost completely prevented the alterations in pancreatic weight , protein content , and blood flow caused by platelet activating factor ( Figs 2–5 ) . |
| 23 | Pancreatic tissue obtained from intact rats infused with saline for five hours released only minute amounts of platelet activating factor ( 1.6 ( 0.9 ) pg/100 mg of wet tissue ) . |
| 24 | Pancreatic specimens from rats infused sc with caerulein showed about nine-fold increase in the content of platelet activating factor ( 13.9 ( 5.5 ) pg/100 mg ) . |
| 25 | This study shows that an excessive stimulation of exocrine pancreas by caerulein leads to an increase in the content of platelet activating factor in the pancreatic tissue and that the pretreatment with platelet activating factor blocker reduces this excessive secretory stimulation by caerulein and significantly ameliorates the biochemical , circulatory , and morphological changes in caerulein-induced pancreatitis . |
| 26 | The origin of platelet activating factor released by the pancreas stimulated with caerulein is not known but it was shown earlier that caerulein and cholecystokinin are capable of increasing the incorporation of labelled acetate into platelet activating factor in the isolated pancreatic lobules and to increase the synthesis of this phospholipid . |
| 27 | The amounts of platelet activating factor like material detected in the pancreatic acini obtained from rats infused with saline in our study was lower than those reported previously for the isolated guinea pig acini from parotic glands and comparable with those found in the gastrointestinal mucosa . |
| 28 | According to our finding caerulein infused at supramaximal dose increased the production of platelet activating factor in the pancreatic tissue by about nine-fold . |
| 29 | Such excessive contents of platelet activating factor could result in further stimulation of acinar cells as platelet activating factor is capable of inducing the secretion of enzymes , of reducing the blood flow , and increasing vascular permeability leading to tissue oedema and injury . |
| 30 | As the pretreatment with TCV-309 reduced the content of platelet activating factor in the pancreas of rats infused with caerulein , it is not excluded that the increase of platelet activating factor in the pancreas is , in part , secondary to the tissue damage by overstimulation with caerulein . |