Example sentences of "platelet [v-ing] [noun] " in BNC.
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| 1 | Platelet binding falls after the menopause and rises in women using the Pill . |
| 2 | Role of platelet activating factor on the fibrinolytic activation in the pathogenesis of gastric mucosal damage induced by endothelin-1 |
| 3 | We determined tissue type plasminogen activator activity in the regional blood sample and the concentration of platelet activating factor in the gastric mucosa after the administration of endothelin-1 in a range of 50–500 pmol/ kg into the left gastric artery of male Wistar rats . |
| 4 | Endothelin-1 increased the tissue type plasminogen activator release and platelet activating factor formation , and induced subsequent gastric mucosal haemorrhagic change in a dose dependent manner . |
| 5 | In addition CV-6209 , a selective platelet activating factor blocker , attenuated the activation of regional tissue type plasminogen activator and the development of mucosal damage induced by endothelin-1 . |
| 6 | The results of this study showed that tissue type plasminogen activator activation may play an important role in the pathogenesis of endothelin induced mucosal injury of rat stomach , and suggest that the platelet activating factor may be involved in the process of regional fibrinolytic activation induced by endothelin-1 . |
| 7 | A previous study has shown that mucosal tissue type plasminogen activator , when released from endothelial cells by platelet activating factor , plays an important role in the process of gastric ulcer formation by inducing macromolecular permeable change in the rat experimental model . |
| 8 | In addition we have also investigated the involvement of platelet activating factor in the endothelin induced fibrinolytic activation . |
| 9 | The level of platelet activating factor in the rat gastric mucosa was determined after the administration of endothelin-1 using a radioimmunoassay method . |
| 10 | Total lipids of mucosal homogenate of rat antrum were extracted by the method of Bligh and Dyer at 4°C in the presence of 50 mM glycine HCl buffer ( pH 2.8 ) in a one phase system to inactivate platelet activating factor acetylhydolase . |
| 11 | The chloroform layer , which contains the purified lipid extract , was isolated and used to determine the platelet activating factor concentration , using the platelet activating factor [ H ] scintillation proximity assay system purchased from Amersham International plc ( UK ) . |
| 12 | The chloroform layer , which contains the purified lipid extract , was isolated and used to determine the platelet activating factor concentration , using the platelet activating factor [ H ] scintillation proximity assay system purchased from Amersham International plc ( UK ) . |
| 13 | The assay system is based on the competition between unlabelled platelet activating factor and a fixed quantity of [ H ] labelled platelet activating factor for a limited number of binding sites on a platelet activating factor specific antibody . |
| 14 | The assay system is based on the competition between unlabelled platelet activating factor and a fixed quantity of [ H ] labelled platelet activating factor for a limited number of binding sites on a platelet activating factor specific antibody . |
| 15 | The assay system is based on the competition between unlabelled platelet activating factor and a fixed quantity of [ H ] labelled platelet activating factor for a limited number of binding sites on a platelet activating factor specific antibody . |
| 16 | The platelet activating factor concentration of mucosa from rat antrum was expressed as pmol/g frozen tissue . |
| 17 | To assess the involvement of platelet activating factor in the endothelin induced tissue type plasminogen activator activation in gastric mucosa , CV-6209 ( a gift from Takeda Pharm Co ) , a selective platelet activating factor blocker , was intravenously administered at a dose of 0.001–0.1 mg/kg five minutes before the injection of endothelin-1 . |
| 18 | To assess the involvement of platelet activating factor in the endothelin induced tissue type plasminogen activator activation in gastric mucosa , CV-6209 ( a gift from Takeda Pharm Co ) , a selective platelet activating factor blocker , was intravenously administered at a dose of 0.001–0.1 mg/kg five minutes before the injection of endothelin-1 . |
| 19 | To investigate one of the mechanisms by which the tissue type plasminogen activator activity in regional blood increased , the platelet activating factor content of the gastric mucosa were measured before , five , and 30 minutes after the administration of endothelin-1 ( 500 pmol/kg ) . |
| 20 | In the gastric mucosa before the endothelin-1 injection , platelet activating factor content was 28.0 ( 7.1 ) pmol/g frozen tissue ( mean ( SD ) n=4 ) . |
| 21 | Platelet activating factor content increased five minutes after the administration of endothelin-1 ( 64.0 ( 11.4 ) n=4 , p<0.01 ) and decreased to 44.5 ( 11 ) at 30 minutes ( p<0.05 ) ( Fig 3 ) . |
| 22 | Endothelin-1 in doses greater than 250 pmol/kg increased the platelet activating factor content at five minutes as compared with the control value ( 27.0 ( 6.1 ) ) ( Fig 1C ) . |
| 23 | The effects of the pretreatment with CV-6209 ( 0.001 , 0.01 , or 0.1 mg/kg ) , a selective platelet activating factor blocker , on both the mucosal injury and the tissue type plasminogen activator activation induced by endothelin-1 500 pmol/kg were tested . |
| 24 | These results suggest the involvement of platelet activating factor in the endothelin induced fibrinolytic activation and subsequently developed mucosal haemorrhagic lesion . |
| 25 | Platelet activating factor is on of lipid mediators that is generated in a variety of cells upon chemical or immune stimulation . |
| 26 | In addition to its biological activities in stimulating platelets and neutrophils , and enhancing vascular permeability , exogenous platelet activating factor has also been shown to be a potent ulcerogen , inducing extensive gastric mucosal damage and hamorrhage associated with septic shock . |
| 27 | Sugatani et al recently determined the alteration of the platelet activating factor contents in rat gastric mucosa during water immersion stress and showed that endogenous platelet activating factor may actually be involved in the process of mucosal injury . |
| 28 | Sugatani et al recently determined the alteration of the platelet activating factor contents in rat gastric mucosa during water immersion stress and showed that endogenous platelet activating factor may actually be involved in the process of mucosal injury . |
| 29 | The present study shows that endothelin-1 can increase the mucosal platelet activating factor content at five minutes after the administration in the rat stomach before the activation of regional tissue type plasminogen activator . |
| 30 | We have shown also that CV-6209 , a platelet activating factor blocker , eliminated the tissue type plasminogen activator activation and mucosal lesion induced by endothelin-1 . |