Example sentences of "with crohn ['s] " in BNC.
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| 1 | Of 504 patients with ulcerative colitis , 54 had 77 relatives with ulcerative colitis and of 133 patients with Crohn 's disease , five had seven relatives with Crohn 's disease . |
| 2 | Of 504 patients with ulcerative colitis , 54 had 77 relatives with ulcerative colitis and of 133 patients with Crohn 's disease , five had seven relatives with Crohn 's disease . |
| 3 | Adequate information was obtained from 637 of the 662 patients ( 96% ) : 504 patients with ulcerative colitis and 133 patients with Crohn 's disease . |
| 4 | Two of these 54 probands had two relatives with Crohn 's disease , and another five probands had seven relatives with Crohn 's disease . |
| 5 | Two of these 54 probands had two relatives with Crohn 's disease , and another five probands had seven relatives with Crohn 's disease . |
| 6 | Five probands with Crohn 's disease had seven relatives with that disease ( four first degree , three second degree ) , and four Crohn 's disease probands had six relatives with ulcerative colitis . |
| 7 | The analysis required that any relative with Crohn 's disease in the ulcerative colitis group was considered to be normal and vice versa in the Crohn 's disease group . |
| 8 | The difficulty in distinguishing between hypotheses was not surprising since only 209 families with Crohn 's disease were available for analysis . |
| 9 | The overall probability for a patient with Crohn 's disease being homozygous for the major locus for Crohn 's disease was 0.07 . |
| 10 | Although the result was not significant , segregation analysis of the families with Crohn 's disease suggested that a major recessive gene is present in about 7% of patients with this disease . |
| 11 | Since the penetrance of this recessive susceptibility gene for Crohn 's disease in the homozygote was almost complete , the risk of disease in a child with one parent with Crohn 's disease induced by this gene and one unaffected parent is about 30×10 -4 — namely , half the estimated gene frequency in the background population . |
| 12 | Hermon-Taylor 's group identified IS900 , a DNA repetitive element in an uncharacterised mycobacterial isolate from a patient with Crohn 's disease . |
| 13 | Stainsby and colleagues ' finding of no significant difference in serum concentrations of antibodies to various mycobacteria , including M paratuberculosis , between patients with Crohn 's disease and ulcerative colitis and healthy controls argues against the hypothesis that Crohn 's disease is caused by M paratuberculosis . |
| 14 | The antibodies were tested in specimens obtained at bowel resection from patients with Crohn 's disease and controls . |
| 15 | A positive reaction was seen in the bowel wall , both in patients with Crohn 's disease and in controls . |
| 16 | The presence of antibodies to certain M paratuberculosis proteins in this condition and the finding , with sophisticated polymerase chain reaction techniques , of DNA associated with mycobacterium in the tissue of two thirds of patients with Crohn 's disease argues for the involvement of mycobacteria in the pathogenesis of the disease . |
| 17 | They also found a significant percentage ( 12% ) of patients with Crohn 's disease positive by their method . |
| 18 | In contrast , none of our patients with Crohn 's disease showed a type 1 pattern of staining and only 33% of ulcerative colitis patients were positive . |
| 19 | In the intestinal mucosa of patients with Crohn 's disease related to disease activity in order to assess the possible role of platelet activating factor in the pathogenesis of Crohn 's disease . |
| 20 | For further characterisation of the platelet aggregation molecules , platelet activating factor extracted from biopsy specimens from patients with Crohn 's disease was pooled , dried and eluted on high performance liquid chromatography . |
| 21 | All these parameters were normal in patients with Crohn 's disease in remission and in controls . |
| 22 | Flexible sigmoidoscopy showed occasional ulceration in the left colon in four of five patients examined during prednisolone therapy and normal mucosa in all patients with Crohn 's disease examined in remission . |
| 23 | The platelet activating factor content of mucosal samples was significantly ( p<0.01 ) higher in patients with Crohn 's disease than in controls , both in the right ( 270 ( 100 ) v ( 11 ) pg/mg net weight ) and left colon ( 280 ( 110 ) v 30 ( 8 ) pg/ mgW ) ( Fig 1 ) . |
| 24 | Five patients with Crohn 's disease after treatment with prednisolone underwent flexible sigmoidoscopy . |
| 25 | There was no significant difference on mucosal content of platelet activating factor in patients with Crohn 's disease in remission than in controls ( p=0.07 ) . |
| 26 | In the present study the aggregating activity of materials obtained from patients with Crohn 's disease was characterised as platelet activating factor according to : ( i ) its retention time from high performance liquid chromatography which was similar to that of synthetic platelet activating factor ; ( ii ) its inhibition by specific platelet activating factor antagonist and phospholipase A2 ( PLA2 ) and no by PLA1 . |
| 27 | Although the present investigation did not reveal more platelet activating factor in colonic mucosa in patients with Crohn 's disease in remission than in controls , this hypothesis could be possible but needs further investigations . |
| 28 | Lysozyme mRNA was investigated in 27 control subjects with histologically normal colonic tissue , in 27 patients with ulcerative colitis ( 14 active , 13 quiescent ) and eight patients with Crohn 's disease ( six active , two quiescent ) . |
| 29 | Lysozyme mRNA positive cells were detected in all sections from the eight patients with Crohn 's disease . |
| 30 | The results in rectal mucosa of twins with Crohn 's disease were widely scattered and affected twins did not differe significantly from normal controls . |