Example sentences of "[noun prp] have make a major [noun] " in BNC.

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1 Already the rosy periwinkle from Madagascar has made a major contribution to curing childhood leukaemia and other blood cancers .
2 Youngsters like Keith Piper have blossomed and though neither are playing today , Alan Donald and Tom Moody have made a major impression and impact with bat and ball .
3 Wimpey became heavily involved in Oman 's drive for modernisation and through Wimpey Alawi has made a major contribution to the fabric of the State by building roads , prestigious offices and government buildings , a police training college , hospitals — including the magnificent £150 million Royal Hospital — and hotels .
4 President Bush has made a major concession to industry over the implementation of the new Clean Air Act , overturning a decision by the Environmental Protection Agency ( EPA ) .
5 Oxford is a national centre for the treatment of problems associated with childbirth , and research in Oxford has made a major contribution to the treatment of these problems .
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