Example sentences of "[vb -s] a large [adj] [noun] " in BNC.

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1 Upon binding InsP 3 , the receptor undergoes a large conformational change which is perhaps related to the coupling process leading to channel opening .
2 The grounds , 2000 acres of parkland , was designed by the famous Capability Brown which contains a large man-made lake crossed by the Grand Bridge designed by Vanbrugh and is reputed to be the finest bridge in Europe .
3 The National Fishing Heritage Centre also contains a large internal dock where the Perseverance fishing smack , floats fully rigged and under sail .
4 The cathedral exterior , largely built of black Tournai marble , has a large central tower and spire and four spired towers grouped around it and flanking the north and south apses ( though it was originally designed for nine towers ) .
5 It has a large round mark on either side of its head and when agitated , weaves its front end from side to side , making itself look unnervingly like a wide-eyed snake .
6 Every cake has a large full-colour photograph and helpful step-by-step illustrations to make the various recipe stages even clearer .
7 At the east it has a large semi-circular apse and Rhenish capped towers ( 338 ) .
8 Worse still , she was phoning from her home in Kilburn , which has a large Irish community .
9 ‘ We 've heard that Middlesbrough has a large Irish community and I 'm sure there must be some Brennans who are related to us , ’ says Leo .
10 The earl of Derby has a large modern mansion in it .
11 The hotel has a large indoor swimming pool , plus a sauna and solarium ( for which a charge is made ) .
12 It has a large black beak and long grey legs .
13 The tropical research should be supported not just because Britain now has a large immigrant population from tropical regions , but because it could be one of the country 's most significant and meaningful contributions to the Third World .
14 The area has a large common seal population , and there are always lots of them lying on the rocks or swimming in the sea .
15 Because it is close to the capital it has a large medical staff .
16 Lin will première the work in San Diego , California , which has a large Chinese population , and if it is successful there he hopes to find a way to perform it in Taiwan .
17 T2 has a large homozygous deletion of the MHC class II region , which encompasses the genes for the two ATP-binding cassette ( ABC ) transporter polypeptides , TAP1 and TAP2 , and the two genes for the MHC-encoded proteasome subunits , Lmp2 and Lmp7 .
18 When Mariner 10 reached Mercury the following data on planetary magnetic fields were to hand : the Earth rotates quickly , almost certainly has a large molten iron core , and has a strong dipole field ; Mars rotates quickly , but probably has no molten iron core , and has no detectable dipole field ; Venus probably has a sizeable molten iron core but rotates slowly , and has no detectable dipole field ( perhaps also because it has no solid inner core — see section 4.2 ) ; the Moon rotates slowly , probably has no liquid iron core , and has no detectable dipole field .
19 The top station has a large revolving restaurant and a sun terrace with wonderful views over Switzerland , including the Eiger , Monch and Jungfrau mountains .
20 Perhaps more important still , each half of the series has a large five-note group in the zones of B and F. Note that these zones , being a tritone apart , are tonally as far apart as is possible .
21 Middlesbrough has a large Asian community which traditionally has not used the CAB .
22 In Rast 's method camphor is used as a solvent since it has a large cryoscopic constant ( see table 6.6 ) .
23 The lid has a large top pocket accessed by a two way zip .
24 The department has a large well-equipped phonetics laboratory with facilities for recording ( both sound and vision ) and for the analysis of speech , speech synthesisers , and its own computers .
25 In his reconstruction , Neal envisages a large central roundel connected to the outer octagon by eight short spokes , although the exact configuration of the centre of this mosaic remains conjectural .
26 This inter-seasonal sale of Impressionist and modern pictures features a large figural group in bronze by Rodin entitled ‘ La Défense ’ ( est. $200,000–300,000 ; £103,100–154,600 ) .
27 For the routed turnings John uses a large old Dominion pattern maker 's lathe , and a large three-jaw chuck .
28 It includes a large photon-counting array which researchers at the Mount stromlo Observatory , near Canberra , developed .
29 Figure 1 shows a large non-repeating pattern that uses almost all the needlebed .
30 As we have noted , literary study in the United States involves a large quantitative spread of the subject , intensive professionalism , and a virtual absence of the national mystique that characterizes English English .
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