Example sentences of "[prep] [art] minor groove " in BNC.
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| 1 | They reported that the nearest neighbour interactions within the GGGCCC motif could produce a widening of the minor groove and an increase of the overall roll . |
| 2 | We have also attempted to use this method to investigate the dissociation of the minor groove binding agent distamycin from DNA . |
| 3 | Although there are no SDS-sequestration data on the dissociation of the minor groove binding drugs , since they do not have suitable absorbance spectra , NMR exchange rates suggest that they are in rapid exchange with the DNA [ 26 ] . |
| 4 | Examination of the minor grooves reveals that the unmodified duplex ( duplex 1 ) can accommodate three first-layer water molecules hydrogen-bonded with thymine O -2 and adenine N -3 , whilst duplex 4 can accommodate one such water molecule . |
| 5 | Arginine 40 and 40' extend from the A helices towards the minor groove , and contact phosphates G10' and G2 . |
| 6 | The more common B I state places the phosphate in a roughly symmetric position with respect to both grooves , while the B II state swings the phosphate around towards the minor groove . |
| 7 | The rotation of the phosphate group towards the minor groove following a B I -B II transition ( involving the central CpG junction ) is shown in figure 8 . |
| 8 | It is worth stressing that both modelling and experimental results show that Xdisp can become strongly positive in these cases ( up to +2Å ) indicating that the rotation of the phosphate groups towards the minor groove pushes the base pairs away and into the major groove . |
| 9 | Rise is also found to increase ( by up to 0.8Å ) and roll becomes strongly negative ( up to -35° ) inducing a local kink of the double helix towards the minor groove ( figure 11 ) . |
| 10 | Once the B II state is generated local structural perturbations lead to a kink towards the minor groove . |
| 11 | The curved , A-tracts containing segment shows the typical phasing of minima with the A-tracts ( 13–16 ) reflecting sequence-dependent curvature towards the minor groove ( 1,7–9,13–15 , 21,25,26 ) . |
| 12 | The repressor antiparallel β -ribbons occupy the major groove of the DNA , whereas the A helices ( see Fig. 2 for helix labelling ) of adjacent dimers form a long , antiparallel protein-protein contact above the minor groove in the centre of the diagram . |
| 13 | This analogue is ideally suited for this purpose since it removes a hydrogen bond acceptor ( adenine N-3 ) from the minor groove , but maintains the essential Watson-Crick hydrogen bonding scheme . |
| 14 | Loss of the stabilising spine of hydration from the minor groove . |
| 15 | These results indicate that removal of N -3 from the minor groove does not prevent the binding of distamycin-A in the minor groove of A-T-rich DNA . |
| 16 | Whilst many base analogues ( 1 ) have been developed to investigate interactions in the major groove of the DNA helix 2'-deoxy-3-deazaadenosine ( d 3C A , Figure 1 ) is one of the few nucleosides that is useful in probing for sequence-specific interactions in the minor groove . |
| 17 | On the basis of this knowledge the replacement of adenine by 3-deazaadenine would be expected to disrupt hydration in the minor groove and therefore destabilise a B-type DNA helix . |
| 18 | We have investigated hydrogen bonding interactions in the minor groove through T m studies performed on duplexes 1 and 4 in the presence of distamycin-A ( Table 2 ) . |
| 19 | The drug distamycin-A is known to bind in the minor groove of d(A-T) rich sequences using the same hydrogen bond acceptor sites ( O -2 and N -3 ) as water , although other stabilising effects including electrostatic and van der Waals interactions are also important ( 18 ) . |
| 20 | These results indicate that removal of N -3 from the minor groove does not prevent the binding of distamycin-A in the minor groove of A-T-rich DNA . |
| 21 | This surprising observation has implications for the application of d 3C A to the study of DNA-protein interactions since it is possible that DNA duplexes containing this analogue may still bind proteins in the minor groove and therefore , the results from such studies need to be interpreted with care . |
| 22 | It appears to be unlikely that reduced hydration in the minor groove plays a major role in destabilising the duplexes used in this study , although removal of bound water may be more significant in sequences containing more contiguous A-T base pairs . |