Example sentences of "have [adv] been known that [adj] " in BNC.

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1 It has long been known that amphibian skin contains strong chemicals .
2 It has long been known that skilled smallholders , owning their own plots of land , can produce very much more from an acre than large-scale farmers with labourers who can not possibly have the same dedication .
3 It has long been known that raw , unrotted FYM does not produce a quick response in crops because the bacteria have to work so hard to break it down , and that fresh pig or poultry dung is too ‘ hot ’ for young plants .
4 It has long been known that pernicious anaemia predisposes to development of gastric adenocarcinoma .
5 It has long been known that phenylalanine hydroxylase deficiency exhibits a wide and continuous range of clinical and biochemical severity , varying from a symptomless disorder with phenylalanine accumulation only just greater than in obligate heterozygotes to a severely handicapping condition with plasma phenylalanine concentrations over 20 times normal .
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